<?xml version="1.0" encoding="utf-8"?>
<!-- http://blog.flexexamples.com/2008/07/19/setting-the-label-color-on-a-disabled-combobox-control-in-flex/ -->
<mx:Application xmlns:mx="http://www.adobe.com/2006/mxml"
        layout="vertical"
        verticalAlign="top"
        backgroundColor="white">

    <mx:Style>
        ComboBox {
            disabledColor: red;
        }
    </mx:Style>

    <mx:Array id="arr">
        <mx:Object label="One" />
        <mx:Object label="Two" />
        <mx:Object label="Three" />
        <mx:Object label="Four" />
        <mx:Object label="Five" />
        <mx:Object label="Six" />
        <mx:Object label="Seven" />
        <mx:Object label="Eight" />
        <mx:Object label="Nine" />
        <mx:Object label="Ten" />
    </mx:Array>

    <mx:ApplicationControlBar dock="true">
        <mx:Form styleName="plain">
            <mx:FormItem label="enabled:">
                <mx:CheckBox id="checkBox"
                        selected="true" />
            </mx:FormItem>
        </mx:Form>
    </mx:ApplicationControlBar>

    <mx:ComboBox id="comboBox"
            dataProvider="{arr}"
            enabled="{checkBox.selected}" />

</mx:Application>